The lab is embracing a new beginning!
From October 2025, we embark on a new adventure at IFOM – the AIRC Institute for Molecular Oncology! Our research will focus on unraveling the RNA regulatory networks that drive tumor plasticity and disease progression.
Milan RNA salon is finally starting!
We are one of 26 laboratories from 12 institutions in the Milan area supporting the RNA salon — meetings fully dedicated to discuss new findings on RNA biology. A special thanks to Ivano Legnini @ Human Technopole.
EMBO workshop — The Spatial Biology of Cancer
Great feedback from all participants. We learnt a lot about spatial omics, generative AI, and modern pathology at the Francis Crick Institute in London. Thanks to Prof Francesca Ciccarelli and Prof Maria Secrier!
Our KRAS story is out on Nature Comm!
Grateful to be part of this exciting and collaborative research on KRAS G12C adaptive resistance and therapy. Kudos goes to Prof. Chiara Ambrogio and Prof. David Santamaria.
Register to our EMBO workshop in London!
Catch up on the spatial biology of cancer with top-notch scientists and learn all about spatially resolved data doing a hackathon at the Francis Crick Institute!
AIRC keeps funding our research!
AIRC will support our studies on RNA processing in pediatric and adult cancers through the BRIDGE funding scheme! A big thanks to AIRC and all the people whose generosity supports the foundation.
C.G.B. Retreat 2023
Our third CGB lab retreat in Varenna! We spent a couple of days in Villa Monastero discussing science and having fun with the Pozzoli lab @ IRCCS Medea!
Oxford Nanopore Cancer Research Seminar 2022
We presented our work on FOXA1-mediated regulation of mRNA processing using long-read sequencing data in Florence!
First intercontinental meeting
Serena and Francesca presented our work on pediatric sarcoma transcriptomes at CTOS in Vancouver, Canada!
C.G.B. @ the AIEOP congress
Serena gave her first official oral presentation discussing novel strategy to apply RNA therapy to sarcomas. Well done Serena!
Our second CGB lab retreat in Varenna!
Three days in Villa Monastero discussing science with friends from the Naccarati lab @ IIGM and the Pozzoli lab @ IRCCS Medea.
FOXA1 drives alternative splicing in prostate cancer
We show that FOXA1 shapes mRNA production of prostate cancer and how these processes reduce transcriptome heterogeneity and influence prognosis.
SIBBM in Rome — and won the poster session!
Our lab presented three projects at the SIBBM conference on "The RNA World 3.0". Francesca with RNAmars was awarded for the best poster! Well done!
Artificial Intelligence in bulk and single-cell RNA-seq
Our review on learning approaches for the analysis of large-scale RNA-sequencing datasets in cancer. We present the major solutions to disentangle tumor heterogeneity of transcriptome profiles.
The Italian SARS-CoV-2 screening
Together with FPO-IRCCS Candiolo units, we are actively monitoring the evolution of SARS-CoV-2 in Piedmont. The lab is mapping the virus lineages circulating in the region. Updates here.
MC farewell
Mariachiara, a very talented internship student, left the lab to complete her education at the University of Milan. She opened our road to RNA methylation! Good luck MC!
The Pandemic
In the horrible pandemic time the lab did not stop. We were lucky and determined enough to smartly work on our research projects.
AIRC is featuring us on Instagram!
Have a look at our interview on AIRC Instagram account. #CancerResearch
'Less is more', our paradigm shift is out!
We introduced GSECA, a probabilistic modelling to identify altered biological processes from heterogeneous high-volume RNA-seq data. Includes a pancancer analysis of PTEN loss and its role in modulating immune-related processes!
'Helper' genes promote cancer
Great collaboration with Francesca Ciccarelli's lab! We contribute to a machine learning algorithm to identify cancer genes in esophageal adenocarcinoma.
At the ECCB/ISCB 2019
Inspiring discussions at the session of Computational Oncology — Heterogeneity and Immune Defence, with Maria Secrier, Nicholas McGranahan, Giovanni Ciriello and all the other speakers!
We move!
C.G.B. and IIGM are now relocating at the FPO IRCCS Candiolo Cancer Institute.
First official C.G.B. poster
Serena presented GSECA at the BITS meeting in Palermo. The first official presentation of our novel paradigm to handle heterogeneity of high-volume RNA-seq data. Less is more!
First official C.G.B. talk
Marco presented our first work on transcriptional regulation of RNA binding proteins in prostate cancer at the BITS annual meeting in Palermo! Well done!
Single Cell Revolution 2.0 : 209 people!
Our free single-cell workshop reached more than 200 participants!