This is the web page of our laboratory, a.k.a. Cancer Genomics and Bioinformatics.The lab has been established in 2019 @ the Italian Institute for Genomic Medicine (IIGM), located within the Candiolo Cancer Institute FPO IRCCS (IT) and at the Biosciences Department of the University of Milan "La Statale".
Artenatively have a look here: C.G.B. @ IIGM
The lab follows three main directions
Deciphering splicing regulation in disease
Assessing tumor genetics and evolution to faster precision oncology
Designing novel algorithms to gain information from genomic Big Data
The future is unwritten
The C.G.B. highlights
We spent two days in the beatuful location of Villa Monastero (Varenna, LC) discussing our research updates with scientists from IFOM (Milan), Tigem (Naples) and Medea (Bosisio Parini, LC) institutes. Here some updates!
Here our review on learning approaches for the analysis of large-scale RNA-sequencing datasets in cancer. We present the major solutions to disentangle tumor heterogeneity of transcriptome profiles for an effective improvement of patient management, check it out!
We introduced a probabilistic modelling, namely GSECA, to identify altered biological process relevant for complex phenotypes from heterogeneous high-volume RNA-seq data. Have a look at our pancancer analysis of PTEN loss and its role in modulating immune-related processes across cancer types!